PhD position in neurobiology of Alzheimer's disease

Vrije Universiteit Amsterdam
  • PhD position in neurobiology of Alzheimer's disease
  • University Graduate
The Center for Neurogenomics and Cognitive Research in Amsterdam (see participates in the Graduate School Neurosciences Amsterdam-Rotterdam ( and is seeking applications for PhD student in neurobiology of Alzheimer's disease

FTE: 1

The project: the role of endolysosomal failure in tau pathology

Alzheimer's Disease (AD) pathology is characterised by amyloid-beta plaques and neurofibrillary tau tangles, as well as defects in the endolysosomal system. How these pathological hallmarks are connected is largely unclear. We have previously found that tau pathology causally disturbs the endolysosomal function. In this project, you will investigate how seeding tau pathology in mouse and human neurons induces these endolysosomal aberrations and how this could lead to tangle formation and neurodegeneration.

Job description

As a PhD student your main tasks and responsibilities are:

  • Cell culture of human and disociated murine neurons.
  • Recombinant protein production, purification and molecular biology.
  • Advanced imaging methods including 3D-STED, live cell imaging, electron microscopy and CLEM.
  • Quantitative analysis of biochemical and imaging data.


We are looking for a student with the following qualifications

  • a master degree in biomedical sciences with neuroscience specialisation
  • hands-on experience with cellular neuroscience, especially endosome biology is an advantage
  • hands-on experience with imaging methods. Electron microscopy experience is an advantage
  • excellent organising skills.
  • a strong motivation to pursue a career in science.

What are we offering?

A challenging position in a socially involved organization. The salary will be in accordance with university regulations for academic personnel and amounts €2,325 (PhD) per month during the first year and increases to €2,972 (PhD) per month during the fourth year, based on a full-time employment. The job profile: is based on the university job ranking system and is vacant for at least 1 FTE.

The appointment will initially be for 1 year. After a satisfactory evaluation of the initial appointment, the contract will be extended for a duration of 4 years.
Additionally, Vrije Universiteit Amsterdam offers excellent fringe benefits and various schemes and regulations to promote a good work/life balance, such as:
  • 8% holiday allowance and 8.3% end-of-year bonus

About Vrije Universiteit Amsterdam

The ambition of Vrije Universiteit Amsterdam is clear: to contribute to a better world through outstanding education and ground-breaking research. And to be a university where personal education and societal involvement play a leading role. Where people from different disciplines and backgrounds work together on innovations and on generating new knowledge. Our teaching and research embrace the whole spectrum of science – from the humanities, the social sciences and the pure sciences through to the life sciences and the medical sciences.

Vrije Universiteit Amsterdam is home to more than 26,500 students. We employ more than 4,600 individuals. The VU campus is easily accessible, located in the heart of Amsterdam’s Zuidas district, a truly inspiring environment for teaching and research.

Diversity is one of our university’s core values. We are an inclusive community, and we believe that diversity and international activities enhance the quality of education and research. We are always looking for people who can enhance diversity on our campus thanks to their background and experience.

The Faculty of Science
The Faculty of Science inspires researchers and students to find sustainable solutions for complex societal issues. From forest fires to big data, from obesity to medicines and from molecules to the moon: our teaching and research programmes cover the full spectrum of the natural sciences. We share knowledge and experience with leading research institutes and industries, both here in the Netherlands and abroad.

Working at the Faculty of Science means working with students, PhD candidates and researchers, all with a clear focus on their field and a broad view of the world. We employ more than 1,250 staff members, and we are home to around 6,000 students.


Are you interested in this position? Please apply via the application button and upload your curriculum vitae and cover letter until 22 March 2020

Applications received by e-mail will not be processed.

Vacancy questions
If you have any questions regarding this vacancy, you may contact:

Name: Dr. J.R.T. van Weering
Position: Supervisor

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